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First Three-Dimensional Structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling

Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis. In contrast, several parasitic protozoa, including Toxoplasma gondii, contain a...

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Detalhes bibliográficos
Main Authors: Sharma, Hitesh, Landau, Mark J., Vargo, Melissa A., Spasov, Krasimir A., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905773/
https://ncbi.nlm.nih.gov/pubmed/24053355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400576t
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