Essential Protein-Protein Interactions between Plasmodium falciparum Thymidylate Synthase and Dihydrofolate Reductase Domains

In Plasmodium falciparum, dihydrofolate reductase and thymidylate synthase activities are conferred by a single 70-kDa bifunctional polypeptide (DHFR-TS, dihydrofolate reductase-thymidylate synthase) which assembles into a functional 140-kDa homodimer. In mammals, the two enzymes are smaller distinc...

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Bibliografiska uppgifter
Huvudupphovsmän: Shallom, Shamira, Zhang, Kai, Jiang, Lei, Rathod, Pradipsinh K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1999
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791593/
https://ncbi.nlm.nih.gov/pubmed/10608839
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