Essential Protein-Protein Interactions between Plasmodium falciparum Thymidylate Synthase and Dihydrofolate Reductase Domains

In Plasmodium falciparum, dihydrofolate reductase and thymidylate synthase activities are conferred by a single 70-kDa bifunctional polypeptide (DHFR-TS, dihydrofolate reductase-thymidylate synthase) which assembles into a functional 140-kDa homodimer. In mammals, the two enzymes are smaller distinc...

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Autores principales: Shallom, Shamira, Zhang, Kai, Jiang, Lei, Rathod, Pradipsinh K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791593/
https://ncbi.nlm.nih.gov/pubmed/10608839
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