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Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

BACKGROUND: Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfDHFR-TS) is a well-defined target of anti-malarial drug, such as pyrimethamine and cycloguanil. Emergence of malaria parasites resistant to these drugs has been shown to be associated with point mutations of the gene c...

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Detalhes bibliográficos
Main Authors: Chaianantakul, Natpasit, Sirawaraporn, Rachada, Sirawaraporn, Worachart
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623654/
https://ncbi.nlm.nih.gov/pubmed/23497065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-91
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