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Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum

Mechanisms of drug resistance in Plasmodium vivax have been difficult to study partially because of the difficulties in culturing the parasite in vitro. This hampers monitoring drug resistance and research to develop or evaluate new drugs. There is an urgent need for a novel method to study mechanis...

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Main Authors: Auliff, Alyson M., Balu, Bharath, Chen, Nanhua, O’Neil, Michael T., Cheng, Qin, Adams, John H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392216/
https://ncbi.nlm.nih.gov/pubmed/22792308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040416
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