Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase

BACKGROUND: In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. Recent work has demonstrated that pyrimethamine-resistance conferring muta...

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Main Authors: Hawkins, Vivian N, Auliff, Alyson, Prajapati, Surendra Kumar, Rungsihirunrat, Kanchana, Hapuarachchi, Hapuarachchige C, Maestre, Amanda, O'Neil, Michael T, Cheng, Qin, Joshi, Hema, Na-Bangchang, Kesara, Sibley, Carol Hopkins
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383903/
https://ncbi.nlm.nih.gov/pubmed/18442404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-7-72
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