Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase

BACKGROUND: In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. Recent work has demonstrated that pyrimethamine-resistance conferring muta...

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Hlavní autoři: Hawkins, Vivian N, Auliff, Alyson, Prajapati, Surendra Kumar, Rungsihirunrat, Kanchana, Hapuarachchi, Hapuarachchige C, Maestre, Amanda, O'Neil, Michael T, Cheng, Qin, Joshi, Hema, Na-Bangchang, Kesara, Sibley, Carol Hopkins
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383903/
https://ncbi.nlm.nih.gov/pubmed/18442404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-7-72
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