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Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum

Mechanisms of drug resistance in Plasmodium vivax have been difficult to study partially because of the difficulties in culturing the parasite in vitro. This hampers monitoring drug resistance and research to develop or evaluate new drugs. There is an urgent need for a novel method to study mechanis...

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Main Authors: Auliff, Alyson M., Balu, Bharath, Chen, Nanhua, O’Neil, Michael T., Cheng, Qin, Adams, John H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392216/
https://ncbi.nlm.nih.gov/pubmed/22792308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040416
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