High-Throughput RT-PCR for small-molecule screening assays

Por Bittker, Joshua A.
Publicado em 2012

Nucleic acid evolution and minimization by nonhomologous random recombination

Por Bittker, Joshua A., Le, Brian V., Liu, David R.
Publicado em 2002

Directed evolution of protein enzymes using nonhomologous random recombination

Por Bittker, Joshua A., Le, Brian V., Liu, Jane M., Liu, David R.
Publicado em 2004

Enhancing the rate of scaffold discovery with diversity-oriented prioritization

Por Swamidass, S. Joshua, Calhoun, Bradley T., Bittker, Joshua A., Bodycombe, Nicole E., Clemons, Paul A.
Publicado em 2011

Utility-Aware Screening with Clique-Oriented Prioritization

Por Swamidass, S. Joshua, Calhoun, Bradley T., Bittker, Joshua A., Bodycombe, Nicole E., Clemons, Paul A.
Publicado em 2011

An Economic Framework to Prioritize Confirmatory Tests Following a High-Throughput Screen

Por Swamidass, S. Joshua, Bittker, Joshua A., Bodycombe, Nicole E., Ryder, Sean P., Clemons, Paul A.
Publicado em 2010

Disrupting fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Por Youngsaye, Willmen, Dockendorff, Chris, Vincent, Benjamin, Hartland, Cathy L., Bittker, Joshua A., Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito
Publicado em 2012

Small-molecule inducers of insulin expression in pancreatic α-cells

Por Fomina-Yadlin, Dina, Kubicek, Stefan, Walpita, Deepika, Dančik, Vlado, Hecksher-Sørensen, Jacob, Bittker, Joshua A., Sharifnia, Tanaz, Shamji, Alykhan, Clemons, Paul A., Wagner, Bridget K., Schreiber, Stuart L.
Publicado em 2010

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Por Weïwer, Michel, Bittker, Joshua A., Lewis, Timothy A., Shimada, Kenichi, Yang, Wan Seok, MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Stockwell, Brent R., Schreiber, Stuart L., Munoz, Benito
Publicado em 2011

Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

Por Park, Sae Woong, Casalena, Dominick, Wilson, Daniel, Dai, Ran, Nag, Partha, Liu, Feng, Boyce, Jim P., Bittker, Joshua, Schreiber, Stuart, Finzel, Barry C., Schnappinger, Dirk, Aldrich, Courtney C.
Publicado no Chem Biol (2014)

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

Por Youngsaye, Willmen, Vincent, Benjamin, Hartland, Cathy L., Morgan, Barbara J., Buhrlage, Sara J., Johnston, Stephen, Bittker, Joshua A., MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Munoz, Benito, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L.
Publicado em 2011

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

Por Youngsaye, Willmen, Hartland, Cathy L, Morgan, Barbara J, Ting, Amal, Nag, Partha P, Vincent, Benjamin, Mosher, Carrie A, Bittker, Joshua A, Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L, Munoz, Benito
Publicado em 2013

GDC-0879, a BRAF(V600E) inhibitor, protects kidney podocytes from death

Por Sieber, Jonas, Wieder, Nicolas, Clark, Abbe, Reitberger, Manuel, Matan, Sofia, Schoenfelder, Jeannine, Zhang, Jianming, Mandinova, Anna, Bittker, Joshua Adam, Gutierrez, Juan, Aygun, Ozan, Udeshi, Namrata, Carr, Steven, Mundel, Peter, Jehle, Andreas Werner, Greka, Anna
Publicado no Cell Chem Biol (2017)

The Drug Repurposing Hub: a next-generation drug library and information resource

Por Corsello, Steven M., Bittker, Joshua A., Liu, Zihan, Gould, Joshua, McCarren, Patrick, Hirschman, Jodi E., Johnston, Stephen E., Vrcic, Anita, Wong, Bang, Khan, Mariya, Asiedu, Jacob, Narayan, Rajiv, Mader, Christopher C., Subramanian, Aravind, Golub, Todd R.
Publicado no Nat Med (2017)

An overview of the challenges in designing, integrating, and delivering BARD: a public chemical biology resource and query portal across multiple organizations, locations, and disc...

Por de Souza, Andrea, Bittker, Joshua, Lahr, David, Brudz, Steve, Chatwin, Simon, Oprea, Tudor I., Waller, Anna, Yang, Jeremy, Southall, Noel, Guha, Rajarshi, Schurer, Stephan, Vempati, Uma, Southern, Mark R., Dawson, Eric S., Clemons, Paul A., Chung, Thomas D.Y.
Publicado no J Biomol Screen (2014)

Evolving BioAssay Ontology (BAO): modularization, integration and applications

Por Abeyruwan, Saminda, Vempati, Uma D, Küçük-McGinty, Hande, Visser, Ubbo, Koleti, Amar, Mir, Ahsan, Sakurai, Kunie, Chung, Caty, Bittker, Joshua A, Clemons, Paul A, Brudz, Steve, Siripala, Anosha, Morales, Arturo J, Romacker, Martin, Twomey, David, Bureeva, Svetlana, Lemmon, Vance, Schürer, Stephan C
Publicado em 2014

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Por Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.
Publicado no Proc Natl Acad Sci U S A (2017)

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

Por Mulrooney, Carol A., Lahr, David L., Quintin, Michael J., Youngsaye, Willmen, Moccia, Dennis, Asiedu, Jacob K., Mulligan, Evan L., Akella, Lakshmi B., Marcaurelle, Lisa A., Montgomery, Philip, Bittker, Joshua A., Clemons, Paul A., Brudz, Stephen, Dandapani, Sivaraman, Duvall, Jeremy R., Tolliday, Nicola J., De Souza, Andrea
Publicado no J Comput Aided Mol Des (2013)

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile

Por Duvall, Jeremy R., Bedard, Leanne, Naylor-Olsen, Adel M., Manson, Abigail L., Bittker, Joshua A., Sun, Wenye, Fitzgerald, Mark E., He, Zhenmin, Lee, Maurice D., Marie, Jean-Charles, Muncipinto, Giovanni, Rush, Diane, Xu, Deming, Xu, Huisheng, Zhang, Mingliang, Earl, Ashlee M., Palmer, Michelle A., Foley, Michael A., Vacca, Joseph P., Scherer, Christina A.
Publicado no ACS Infect Dis (2017)

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

Por Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Publicado no Gigascience (2017)