Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

Biotin biosynthesis is essential for survival and persistence of Mycobacterium tuberculosis (Mtb) in vivo. The aminotransferase BioA, which catalyzes the antepenultimate step in the biotin pathway, has been established as a promising target due to its vulnerability to chemical inhibition. We perform...

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Pubblicato in:Chem Biol
Autori principali: Park, Sae Woong, Casalena, Dominick, Wilson, Daniel, Dai, Ran, Nag, Partha, Liu, Feng, Boyce, Jim P., Bittker, Joshua, Schreiber, Stuart, Finzel, Barry C., Schnappinger, Dirk, Aldrich, Courtney C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305006/
https://ncbi.nlm.nih.gov/pubmed/25556942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.11.012
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