Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

Biotin biosynthesis is essential for survival and persistence of Mycobacterium tuberculosis (Mtb) in vivo. The aminotransferase BioA, which catalyzes the antepenultimate step in the biotin pathway, has been established as a promising target due to its vulnerability to chemical inhibition. We perform...

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Vydáno v:Chem Biol
Hlavní autoři: Park, Sae Woong, Casalena, Dominick, Wilson, Daniel, Dai, Ran, Nag, Partha, Liu, Feng, Boyce, Jim P., Bittker, Joshua, Schreiber, Stuart, Finzel, Barry C., Schnappinger, Dirk, Aldrich, Courtney C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305006/
https://ncbi.nlm.nih.gov/pubmed/25556942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.11.012
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