Caricamento...

Mechanism-Based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

BioA catalyzes the second step of biotin biosynthesis and this enzyme represents a potential target to develop new antitubercular agents. Herein we report the design, synthesis, and biochemical characterization of a mechanism-based inhibitor (1) featuring a 3,6-dihydropyrid-2-one heterocycle that co...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Shi, Ce, Geders, Todd W., Park, Sae Woong, Wilson, Daniel J., Boshoff, Helena I., Orisadipe, Abayomi, Barry, Clifton E., Schnappinger, Dirk, Finzel, Barry C., Aldrich, Courtney C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222238/
https://ncbi.nlm.nih.gov/pubmed/21988601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204036t
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !