A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis

Cofactor biosynthetic pathways represent a rich source of potential antibiotic targets. The second step in biotin biosynthesis is performed by BioA, a pyridoxal 5′-phosphate (PLP) dependent enzyme. This enzyme has been confirmed as a candidate target in Mycobacterium tuberculosis; however, the curre...

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Hlavní autoři: Wilson, Daniel J., Shi, Ce, Duckworth, Benjamin P., Muretta, Joseph M., Manjunatha, Ujjini, Sham, Yuk Y., Thomas, David D., Aldrich, Courtney C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135573/
https://ncbi.nlm.nih.gov/pubmed/21621502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.05.003
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