Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

7,8-diaminopelargonic acid synthase (BioA) of Mycobacterium tuberculosis is a recently validated target for therapeutic intervention in the treatment of tuberculosis (TB). Using biophysical fragment screening and structural characterization of compounds, we have identified a potent aryl hydrazine in...

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Hlavní autoři: Dai, Ran, Wilson, Daniel J., Geders, Todd W., Aldrich, Courtney C., Finzel, Barry C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020011/
https://ncbi.nlm.nih.gov/pubmed/24482078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300748
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