Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA

[Image: see text] The PLP-dependent transaminase (BioA) of Mycobacterium tuberculosis and other pathogens that catalyzes the second step of biotin biosynthesis is a now well-validated target for antibacterial development. Fragment screening by differential scanning fluorimetry has been performed to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Dai, Ran, Geders, Todd W., Liu, Feng, Park, Sae Woong, Schnappinger, Dirk, Aldrich, Courtney C., Finzel, Barry C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687966/
https://ncbi.nlm.nih.gov/pubmed/26068403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00092
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