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Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis
The mycobacterial biotin protein ligase (MtBPL) globally regulates lipid metabolism in Mtb through the posttranslational biotinylation of acyl coenzyme A carboxylases involved in lipid biosynthesis that catalyze the first step in fatty acid biosynthesis and pyruvate coenzyme A carboxylase, a glucone...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225891/ https://ncbi.nlm.nih.gov/pubmed/22118677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.08.013 |
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