Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors

Mycobacterium tuberculosis (Mtb) responsible for both latent and symptomatic tuberculosis (TB) remains the second leading cause of mortality among infectious diseases worldwide. Mycobacterial biotin protein ligase (MtBPL) is an essential enzyme in Mtb and regulates lipid metabolism through the post-...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Bockman, Matthew R., Kalinda, Alvin S., Petrelli, Riccardo, De la Mora-Rey, Teresa, Tiwari, Divya, Liu, Feng, Dawadi, Surrendra, Nandakumar, Madhumitha, Rhee, Kyu Y., Schnappinger, Dirk, Finzel, Barry C., Aldrich, Courtney C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667793/
https://ncbi.nlm.nih.gov/pubmed/26299766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00719
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