Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors

Mycobacterium tuberculosis (Mtb) responsible for both latent and symptomatic tuberculosis (TB) remains the second leading cause of mortality among infectious diseases worldwide. Mycobacterial biotin protein ligase (MtBPL) is an essential enzyme in Mtb and regulates lipid metabolism through the post-...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Bockman, Matthew R., Kalinda, Alvin S., Petrelli, Riccardo, De la Mora-Rey, Teresa, Tiwari, Divya, Liu, Feng, Dawadi, Surrendra, Nandakumar, Madhumitha, Rhee, Kyu Y., Schnappinger, Dirk, Finzel, Barry C., Aldrich, Courtney C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667793/
https://ncbi.nlm.nih.gov/pubmed/26299766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00719
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