Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation

[Image: see text] Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is the leading cause of bacterial infectious disease mortality. Biotin protein ligase (BirA) globally regulates lipid metabolism in Mtb through the posttranslational biotinylation of acyl coenzyme A carboxylas...

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Autores principales: Shi, Ce, Tiwari, Divya, Wilson, Daniel J., Seiler, Christopher L., Schnappinger, Dirk, Aldrich, Courtney C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2013
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867986/
https://ncbi.nlm.nih.gov/pubmed/24363833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400328a
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