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Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation

[Image: see text] Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is the leading cause of bacterial infectious disease mortality. Biotin protein ligase (BirA) globally regulates lipid metabolism in Mtb through the posttranslational biotinylation of acyl coenzyme A carboxylas...

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Main Authors: Shi, Ce, Tiwari, Divya, Wilson, Daniel J., Seiler, Christopher L., Schnappinger, Dirk, Aldrich, Courtney C.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2013
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867986/
https://ncbi.nlm.nih.gov/pubmed/24363833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400328a
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