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Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation

[Image: see text] Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is the leading cause of bacterial infectious disease mortality. Biotin protein ligase (BirA) globally regulates lipid metabolism in Mtb through the posttranslational biotinylation of acyl coenzyme A carboxylas...

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Autors principals: Shi, Ce, Tiwari, Divya, Wilson, Daniel J., Seiler, Christopher L., Schnappinger, Dirk, Aldrich, Courtney C.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867986/
https://ncbi.nlm.nih.gov/pubmed/24363833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400328a
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