GDC-0879, a BRAF(V600E) inhibitor, protects kidney podocytes from death

Progressive kidney diseases affect approximately 500 million people worldwide. Podocytes are terminally differentiated cells of the kidney filter, whose loss leads to disease progression and kidney failure. To date, there are no therapies to promote podocyte survival. Drug repurposing may therefore...

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Publicat a:Cell Chem Biol
Autors principals: Sieber, Jonas, Wieder, Nicolas, Clark, Abbe, Reitberger, Manuel, Matan, Sofia, Schoenfelder, Jeannine, Zhang, Jianming, Mandinova, Anna, Bittker, Joshua Adam, Gutierrez, Juan, Aygun, Ozan, Udeshi, Namrata, Carr, Steven, Mundel, Peter, Jehle, Andreas Werner, Greka, Anna
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819995/
https://ncbi.nlm.nih.gov/pubmed/29249695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.11.006
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