GDC-0879, a BRAF(V600E) inhibitor, protects kidney podocytes from death

Progressive kidney diseases affect approximately 500 million people worldwide. Podocytes are terminally differentiated cells of the kidney filter, whose loss leads to disease progression and kidney failure. To date, there are no therapies to promote podocyte survival. Drug repurposing may therefore...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Sieber, Jonas, Wieder, Nicolas, Clark, Abbe, Reitberger, Manuel, Matan, Sofia, Schoenfelder, Jeannine, Zhang, Jianming, Mandinova, Anna, Bittker, Joshua Adam, Gutierrez, Juan, Aygun, Ozan, Udeshi, Namrata, Carr, Steven, Mundel, Peter, Jehle, Andreas Werner, Greka, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819995/
https://ncbi.nlm.nih.gov/pubmed/29249695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.11.006
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