Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer’s Disease Pathogenesis

por Zoltowska, Katarzyna Marta, Berezovska, Oksana
Publicado no Mol Neurobiol (2017)

Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation

por Zoltowska, Katarzyna Marta, Maesako, Masato, Berezovska, Oksana
Publicado no Mol Med (2016)

Synapsin 1 promotes Aβ generation via BACE1 modulation

por Maesako, Masato, Zoltowska, Katarzyna M., Berezovska, Oksana
Publicado no PLoS One (2019)

Novel interaction between Alzheimer’s disease-related protein presenilin 1 and glutamate transporter 1

por Zoltowska, Katarzyna Marta, Maesako, Masato, Meier, Joshua, Berezovska, Oksana
Publicado no Sci Rep (2018)

Visualizing Interaction of Proteins relevant to Alzheimer’s Disease in intact Cells

por Thomas, Anne V., Berezovska, Oksana, Hyman, Bradley T., von Arnim, Christine A. F.
Publicado em 2008

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

por Uemura, Kengo, Farner, Katherine C, Nasser-Ghodsi, Navine, Jones, Phill, Berezovska, Oksana
Publicado em 2011

Synaptotagmins interact with APP and promote Aβ generation

por Gautam, Vivek, D’Avanzo, Carla, Berezovska, Oksana, Tanzi, Rudolph E., Kovacs, Dora M.
Publicado no Mol Neurodegener (2015)

Oxidative stress and lipid peroxidation are upstream of amyloid pathology

por Arimon, Muriel, Takeda, Shuko, Post, Kathryn L., Svirsky, Sarah, Hyman, Bradley T., Berezovska, Oksana
Publicado no Neurobiol Dis (2015)

Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging

por Berezovska, Oksana, Ramdya, Pavan, Skoch, Jesse, Wolfe, Michael S., Bacskai, Brian J., Hyman, Bradley T.
Publicado no J Neurosci (2003)

Visualization of PS/γ-Secretase Activity in Living Cells

por Maesako, Masato, Sekula, Nicole M., Aristarkhova, Anna, Feschenko, Polina, Anderson, Lauren C., Berezovska, Oksana
Publicado no iScience (2020)

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

por Houser, Mei C. Q., Turchyna, Yuliia, Perrin, Florian, Chibnik, Lori, Berezovska, Oksana, Maesako, Masato
Publicado no Biosensors (Basel) (2021)

Presenilin 1 increases association with synaptotagmin 1 during normal aging

por Keller, Laura J., Sekula, Nicole M., Svirsky, Sarah, Maesako, Masato, Zoltowska, Katarzyna M., Berezovska, Oksana
Publicado no Neurobiol Aging (2019)

A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells

por Houser, Mei CQ, Hou, Steven S, Perrin, Florian, Turchyna, Yuliia, Bacskai, Brian J, Berezovska, Oksana, Maesako, Masato
Publicado no Sensors (Basel) (2020)

PRESENILIN-1 ADOPTS PATHOGENIC CONFORMATION IN NORMAL AGING AND IN SPORADIC ALZHEIMER’S DISEASE

por Wahlster, Lara, Arimon, Muriel, Nasser-Ghodsi, Navine, Post, Kathryn Leigh, Serrano-Pozo, Alberto, Uemura, Kengo, Berezovska, Oksana
Publicado em 2012

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

por Tetzlaff, Julie E., Putcha, Preeti, Outeiro, Tiago F., Ivanov, Alexander, Berezovska, Oksana, Hyman, Bradley T., McLean, Pamela J.
Publicado em 2008

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

por Zoltowska, Katarzyna Marta, Maesako, Masato, Lushnikova, Iryna, Takeda, Shuko, Keller, Laura J., Skibo, Galina, Hyman, Bradley T., Berezovska, Oksana
Publicado no Mol Neurodegener (2017)

Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein

por Berezovska, Oksana, Lleo, Alberto, Herl, Lauren D., Frosch, Matthew P., Stern, Edward A., Bacskai, Brian J., Hyman, Bradley T.
Publicado no J Neurosci (2005)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

por Uemura, Kengo, Farner, Katherine C., Hashimoto, Tadafumi, Nasser-Ghodsi, Navine, Wolfe, Michael S., Koo, Edward H., Hyman, Bradley T., Berezovska, Oksana
Publicado em 2010

Neuronal Activity and Secreted Amyloid β Lead to Altered Amyloid β Precursor Protein and Presenilin 1 Interactions

por Li, Xuejing, Uemura, Kengo, Hashimoto, Tadafumi, Arimon, Muriel, Lill, Christina M., Palazzolo, Isabella, Krainc, Dimitri, Hyman, Bradley T., Berezovska, Oksana
Publicado em 2012

Convergence of pathology in dementia with Lewy bodies and Alzheimer’s disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease

por Winslow, Ashley R., Moussaud, Simon, Zhu, Liya, Post, Katherine L., Dickson, Dennis W., Berezovska, Oksana, McLean, Pamela J.
Publicado em 2014