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Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production
BACKGROUND: Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to influence PS1-dependent generation of distinct amyloid β (Aβ) species. However,...
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| 出版年: | Mol Neurodegener |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5307796/ https://ncbi.nlm.nih.gov/pubmed/28193235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0159-y |
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