Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

BACKGROUND: Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to influence PS1-dependent generation of distinct amyloid β (Aβ) species. However,...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Zoltowska, Katarzyna Marta, Maesako, Masato, Lushnikova, Iryna, Takeda, Shuko, Keller, Laura J., Skibo, Galina, Hyman, Bradley T., Berezovska, Oksana
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307796/
https://ncbi.nlm.nih.gov/pubmed/28193235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0159-y
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