Presenilin 1 increases association with synaptotagmin 1 during normal aging

Presenilin 1 (PS1), the catalytic component of gamma secretase, associates with synaptotagmin 1 (Syt-1). This interaction is decreased in the brains of patients with sporadic Alzheimer’s disease. However, it remains unclear how this interaction changes during normal aging. Because aging is a risk fa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Aging
Prif Awduron: Keller, Laura J., Sekula, Nicole M., Svirsky, Sarah, Maesako, Masato, Zoltowska, Katarzyna M., Berezovska, Oksana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325863/
https://ncbi.nlm.nih.gov/pubmed/31864759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.10.006
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