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Synaptotagmins interact with APP and promote Aβ generation
BACKGROUND: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, proteins regulating Aβ generation at the synapse have not been characterized. Here,...
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| Publicado no: | Mol Neurodegener |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4511450/ https://ncbi.nlm.nih.gov/pubmed/26202512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0028-5 |
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