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BACE1 activity regulates cell surface contactin-2 levels

BACKGROUND: Although BACE1 is a major therapeutic target for Alzheimer’s disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-med...

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Detalhes bibliográficos
Main Authors: Gautam, Vivek, D’Avanzo, Carla, Hebisch, Matthias, Kovacs, Dora M, Kim, Doo Yeon
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899608/
https://ncbi.nlm.nih.gov/pubmed/24405708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-4
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