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BACE1 activity regulates cell surface contactin-2 levels

BACKGROUND: Although BACE1 is a major therapeutic target for Alzheimer’s disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-med...

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Sonraí Bibleagrafaíochta
Main Authors: Gautam, Vivek, D’Avanzo, Carla, Hebisch, Matthias, Kovacs, Dora M, Kim, Doo Yeon
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899608/
https://ncbi.nlm.nih.gov/pubmed/24405708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-4
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