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BACE1 regulates voltage-gated sodium channels and neuronal activity
BACE1 activity is significantly increased in the brains of Alzheimer’s disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) β2-subunit (β2), a type I membrane protein that covalently binds to Na(v)1 α-subunits, is a substrate for BACE1 and γ-secr...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747787/ https://ncbi.nlm.nih.gov/pubmed/17576410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1602 |
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