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Alzheimer’s secretases regulate voltage-gated sodium channels
BACE1 and presenilin (PS)/γ-secretase are primary proteolytic enzymes responsible for the generation of pathogenic amyloid β-peptides (Aβ) in Alzheimer’s disease. We and others have found that β-subunits of the voltage-gated sodium channel (Na(v)βs) also undergo sequential proteolytic cleavages medi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964382/ https://ncbi.nlm.nih.gov/pubmed/20817076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.08.048 |
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