BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels

BACE1 and presenilin (PS)/γ-secretase play a major role in Alzheimer's disease pathogenesis by regulating amyloid-β peptide generation. We recently showed that these secretases also regulate the processing of voltage-gated sodium channel auxiliary β-subunits and thereby modulate membrane excita...

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Bibliographic Details
Main Authors: Sachse, Carolyn C., Kim, Young Hye, Agsten, Marianne, Huth, Tobias, Alzheimer, Christian, Kovacs, Dora M., Kim, Doo Yeon
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2013
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659364/
https://ncbi.nlm.nih.gov/pubmed/23504710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-214056
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