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Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
BACKGROUND: The voltage-gated sodium channel β2 subunit (Navβ2) is a physiological substrate of BACE1 (β-site APP cleaving enzyme) and γ-secretase, two proteolytic enzymes central to Alzheimer's disease pathogenesis. Previously, we have found that the processing of Navβ2 by BACE1 and γ-secretas...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3022600/ https://ncbi.nlm.nih.gov/pubmed/21182789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-61 |
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