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The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells
BACKGROUND: Familial Alzheimer's Disease (FAD) mutations in presenilin (PS) modulate PS/γ-secretase activity and therefore contribute to AD pathogenesis. Previously, we found that PS/γ-secretase cleaves voltage-gated sodium channel β2 subunits (Na(v)β2), releases the intracellular domain of Na(...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3940070/ https://ncbi.nlm.nih.gov/pubmed/24217025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000354669 |
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