BACE1 regulates voltage-gated sodium channels and neuronal activity

BACE1 activity is significantly increased in the brains of Alzheimer’s disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) β2-subunit (β2), a type I membrane protein that covalently binds to Na(v)1 α-subunits, is a substrate for BACE1 and γ-secr...

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Autori principali: Kim, Doo Yeon, Carey, Bryce W., Wang, Haibin, Ingano, Laura A. M., Binshtok, Alexander M., Wertz, Mary H., Pettingell, Warren H., He, Ping, Lee, Virginia M.-Y., Woolf, Clifford J., Kovacs, Dora M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747787/
https://ncbi.nlm.nih.gov/pubmed/17576410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1602
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