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γ-Secretase modulators reduce endogenous amyloid β(42) levels in human neural progenitor cells without altering neuronal differentiation

Soluble γ-secretase modulators (SGSMs) selectively decrease toxic amyloid β (Aβ) peptides (Aβ(42)). However, their effect on the physiologic functions of γ-secretase has not been tested in human model systems. γ-Secretase regulates fate determination of neural progenitor cells. Thus, we studied the...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: D’Avanzo, Carla, Sliwinski, Christopher, Wagner, Steven L., Tanzi, Rudolph E., Kim, Doo Yeon, Kovacs, Dora M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511200/
https://ncbi.nlm.nih.gov/pubmed/25903103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271015
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