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γ-Secretase modulators reduce endogenous amyloid β(42) levels in human neural progenitor cells without altering neuronal differentiation
Soluble γ-secretase modulators (SGSMs) selectively decrease toxic amyloid β (Aβ) peptides (Aβ(42)). However, their effect on the physiologic functions of γ-secretase has not been tested in human model systems. γ-Secretase regulates fate determination of neural progenitor cells. Thus, we studied the...
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| Опубликовано в: : | FASEB J |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Federation of American Societies for Experimental Biology
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4511200/ https://ncbi.nlm.nih.gov/pubmed/25903103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271015 |
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