Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species

[Image: see text] Alzheimer’s disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wagner, Steven L., Zhang, Can, Cheng, Soan, Nguyen, Phuong, Zhang, Xulun, Rynearson, Kevin D., Wang, Rong, Li, Yueming, Sisodia, Sangram S., Mobley, William C., Tanzi, Rudolph E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929337/
https://ncbi.nlm.nih.gov/pubmed/24401146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401537v
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados