Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein

Alzheimer disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. Four genes have been established to either cause familial early onset AD (APP, PSEN1, and PSEN2) or to increase susceptibility for late onset AD (APOE). To date ∼80% of the late onset AD ge...

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Detalhes bibliográficos
Main Authors: Zhang, Can, Browne, Andrew, Child, Daniel, DiVito, Jason R., Stevenson, Jesse A., Tanzi, Rudolph E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838273/
https://ncbi.nlm.nih.gov/pubmed/20097758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079079
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