Amyloid-β Production Via Cleavage of Amyloid-β Protein Precursor is Modulated by Cell Density

Mounting evidence suggests that Alzheimer disease (AD) is caused by the accumulation of the small peptide, Aβ, a proteolytic cleavage product of amyloid-β protein precursor (AβPP; or APP). Aβ is generated through a serial cleavage of APP by β- and γ-secretase. Aβ40 and Aβ42 are the two main componen...

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Bibliographic Details
Main Authors: Zhang, Can, Browne, Andrew, DiVito, Jason R., Stevenson, Jesse A., Romano, Donna, Dong, Yuanlin, Xie, Zhongcong, Tanzi, Rudolph E.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272776/
https://ncbi.nlm.nih.gov/pubmed/20847415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100816
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