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Amyloid-β Production Via Cleavage of Amyloid-β Protein Precursor is Modulated by Cell Density
Mounting evidence suggests that Alzheimer disease (AD) is caused by the accumulation of the small peptide, Aβ, a proteolytic cleavage product of amyloid-β protein precursor (AβPP; or APP). Aβ is generated through a serial cleavage of APP by β- and γ-secretase. Aβ40 and Aβ42 are the two main componen...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272776/ https://ncbi.nlm.nih.gov/pubmed/20847415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100816 |
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