Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

Recent evidence suggests involvement of biometal homeostasis in the pathological mechanisms in Alzheimer's disease (AD). For example, increased intracellular copper or zinc has been linked to a reduction in secreted levels of the AD-causing amyloid-β peptide (Aβ). However, little is known about...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Gerber, Hermeto, Wu, Fang, Dimitrov, Mitko, Garcia Osuna, Guillermo M., Fraering, Patrick C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339758/
https://ncbi.nlm.nih.gov/pubmed/28096459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754101
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