Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons

Rare, familial, early-onset autosomal dominant forms of familial Alzheimer's disease (FAD) are caused by mutations in genes encoding β-amyloid (Aβ) precursor protein (APP), presenilin-1 (PS1), and presenilin-2. Each of these genes is expressed ubiquitously throughout the CNS, but a widely held...

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Detalhes bibliográficos
Main Authors: Veeraraghavalu, Karthikeyan, Zhang, Can, Zhang, Xiaoqiong, Tanzi, Rudolph E., Sisodia, Sangram S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942582/
https://ncbi.nlm.nih.gov/pubmed/24599465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5079-13.2014
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