FAD-linked human Presenilin 1 variants impair environmental enrichment-induced hippocampal neural progenitor cell proliferation and differentiation in a non-cell-autonomous manner

Presenilin 1 (PS1) regulates environmental enrichment (EE)-mediated neural progenitor cell (NPC) proliferation and neurogenesis in the adult hippocampus. We now report that transgenic mice that ubiquitously express human PS1 variants linked to early-onset familial Alzheimer's disease (FAD) neit...

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Detalhes bibliográficos
Main Authors: Choi, Se Hoon, Veeraraghavalu, Karthikeyan, Lazarov, Orly, Marler, Seoan, Ransohoff, Richard M., Ramirez, Jan Marino, Sisodia, Sangram S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489017/
https://ncbi.nlm.nih.gov/pubmed/18760694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.07.033
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