Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling

The vast majority of pedigrees with familial Alzheimer's disease (FAD) are caused by inheritance of mutations in the PSEN1 1 gene. While genetic ablation studies have revealed a role for presenilin 1 (PS1) in embryonic neurogenesis, little information has emerged regarding the potential effects...

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Main Authors: Veeraraghavalu, Karthikeyan, Choi, Se Hoon, Zhang, Xiaoqiong, Sisodia, Sangram S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879010/
https://ncbi.nlm.nih.gov/pubmed/20484632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0527-10.2010
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