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Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species
[Image: see text] Alzheimer’s disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), th...
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| Asıl Yazarlar: | , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American
Chemical Society
2014
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929337/ https://ncbi.nlm.nih.gov/pubmed/24401146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401537v |
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