Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Abeta42 levels without inhibiting epsilon-site cleavage of APP and Notch, t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kounnas, Maria Z., Danks, Anne M., Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J., Velicelebi, Gonul, Stauderman, Kenneth A., Comer, William T., Mobley, William C., Li, Yue-Ming, Sisodia, Sangram S., Tanzi, Rudolph E., Wagner, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947312/
https://ncbi.nlm.nih.gov/pubmed/20826309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.018
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados