Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Abeta42 levels without inhibiting epsilon-site cleavage of APP and Notch, t...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kounnas, Maria Z., Danks, Anne M., Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J., Velicelebi, Gonul, Stauderman, Kenneth A., Comer, William T., Mobley, William C., Li, Yue-Ming, Sisodia, Sangram S., Tanzi, Rudolph E., Wagner, Steven L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2010
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947312/
https://ncbi.nlm.nih.gov/pubmed/20826309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.018
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