Synaptotagmins interact with APP and promote Aβ generation

BACKGROUND: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, proteins regulating Aβ generation at the synapse have not been characterized. Here,...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Neurodegener
Main Authors: Gautam, Vivek, D’Avanzo, Carla, Berezovska, Oksana, Tanzi, Rudolph E., Kovacs, Dora M.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511450/
https://ncbi.nlm.nih.gov/pubmed/26202512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0028-5
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