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CHIP Targets Toxic α-Synuclein Oligomers for Degradation
α-Synuclein (αSyn) can self-associate, forming oligomers, fibrils, and Lewy bodies, the pathological hallmark of Parkinson disease. Current dogma suggests that oligomeric αSyn intermediates may represent the most toxic αSyn species. Here, we studied the effect of a potent molecular chaperone, CHIP (...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936239/ https://ncbi.nlm.nih.gov/pubmed/18436529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802283200 |
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