Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent α-Synuclein Oligomer Formation and Rescue α-Synuclein-Induced Toxicity

Aggregation of α-synuclein (αsyn) is a hallmark of sporadic and familial Parkinson's disease (PD) and dementia with Lewy bodies. Lewy bodies contain αsyn and several heat shock proteins (Hsp), a family of molecular chaperones up-regulated by the cell under stress. We have previously shown that...

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Autors principals: Putcha, Preeti, Danzer, Karin M., Kranich, Lisa R., Scott, Anisa, Silinski, Melanie, Mabbett, Sarah, Hicks, Carol D., Veal, James M., Steed, Paul M., Hyman, Bradley T., McLean, Pamela J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Cellular and Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835433/
https://ncbi.nlm.nih.gov/pubmed/19934398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.158436
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