Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent α-Synuclein Oligomer Formation and Rescue α-Synuclein-Induced Toxicity

Aggregation of α-synuclein (αsyn) is a hallmark of sporadic and familial Parkinson's disease (PD) and dementia with Lewy bodies. Lewy bodies contain αsyn and several heat shock proteins (Hsp), a family of molecular chaperones up-regulated by the cell under stress. We have previously shown that...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Putcha, Preeti, Danzer, Karin M., Kranich, Lisa R., Scott, Anisa, Silinski, Melanie, Mabbett, Sarah, Hicks, Carol D., Veal, James M., Steed, Paul M., Hyman, Bradley T., McLean, Pamela J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2010
Materias:
Cellular and Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835433/
https://ncbi.nlm.nih.gov/pubmed/19934398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.158436
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares