Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

The paradoxical appearance of aggregated α-synuclein (αsyn) in naive transplanted embryonic stem cells in Parkinson's disease (PD) brains has recently been reported, highlighting the possibility of neuron to neuron transmission of αsyn in PD. Here, we demonstrate in a cellular model the presenc...

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Bibliografiset tiedot
Päätekijät: Danzer, Karin M., Ruf, Wolfgang P., Putcha, Preeti, Joyner, Daniel, Hashimoto, Tadafumi, Glabe, Charles, Hyman, Bradley T., McLean, Pamela J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Federation of American Societies for Experimental Biology 2011
Aiheet:
Research Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005424/
https://ncbi.nlm.nih.gov/pubmed/20876215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-164624
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