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Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

The paradoxical appearance of aggregated α-synuclein (αsyn) in naive transplanted embryonic stem cells in Parkinson's disease (PD) brains has recently been reported, highlighting the possibility of neuron to neuron transmission of αsyn in PD. Here, we demonstrate in a cellular model the presenc...

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Detalhes bibliográficos
Main Authors: Danzer, Karin M., Ruf, Wolfgang P., Putcha, Preeti, Joyner, Daniel, Hashimoto, Tadafumi, Glabe, Charles, Hyman, Bradley T., McLean, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005424/
https://ncbi.nlm.nih.gov/pubmed/20876215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-164624
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