Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

BACKGROUND: Misfolding, oligomerization, and fibrillization of α-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders. Although fibrillar α-synuclein is a major component of Lewy bodies (LBs), recent data implicate prefibrilla...

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Detalhes bibliográficos
Main Authors: Outeiro, Tiago Fleming, Putcha, Preeti, Tetzlaff, Julie E., Spoelgen, Robert, Koker, Mirjam, Carvalho, Filipe, Hyman, Bradley T., McLean, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270899/
https://ncbi.nlm.nih.gov/pubmed/18382657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001867
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