Dopamine-Induced Conformational Changes in Alpha-Synuclein

BACKGROUND: Oligomerization and aggregation of α-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, α-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using detergent extraction methods [2], [3], [4]...

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Hlavní autoři: Outeiro, Tiago F., Klucken, Jochen, Bercury, Kathryn, Tetzlaff, Julie, Putcha, Preeti, Oliveira, Luis M. A., Quintas, Alexandre, McLean, Pamela J., Hyman, Bradley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731858/
https://ncbi.nlm.nih.gov/pubmed/19730729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006906
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