Exosomal cell-to-cell transmission of alpha synuclein oligomers

BACKGROUND: Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with recent evidence implicating oligomeric and pre-fibrillar forms of αsyn as the pathogenic species. Recent in vitro st...

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Main Authors: Danzer, Karin M, Kranich, Lisa R, Ruf, Wolfgang P, Cagsal-Getkin, Ozge, Winslow, Ashley R, Zhu, Liya, Vanderburg, Charles R, McLean, Pamela J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483256/
https://ncbi.nlm.nih.gov/pubmed/22920859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-42
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